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③要有足够的营养供给。每种建筑材料中都含有不同程度上的营养物质。根据不同建材能提供霉菌生长的营养物水平，将建材分为四个等级。即使是那些不能直接提供营养物的建材(如金属、塑料制品等)，由于其积累的灰尘可能含有各种微生物代谢物，动植物的残骸，以及一些脂肪性毛屑，而为霉菌生长提供营养物。现已有很多关于霉菌对无机类建筑材料侵蚀的报告。
④暴露时间问题。弄清楚霉菌生长所需的时间是个非常复杂的事情：生长需时取决于温度、周边相对湿度、材料的含湿量、日夜交替、空气流动、环境波动、材质、材质表面特性及其周围的杂质。 当环境温度在5℃～5O℃，相对湿度总是在80%以上，数周或数月通常就能引发霉菌生长。
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